ВИЧ-ассоциированный туберкулез

Нелеченая инфекция вируса иммунодефицита человека (ВИЧ) значительно увеличивает риск туберкулеза, который остается наиболее распространенной причиной госпитализации и смерти во всем мире среди людей с ВИЧ-инфекцией в эпоху антиретровирусной терапии (АРТ). Проблемы, связанные с диагностикой туберкулеза у людей с ВИЧ-инфекцией, могут привести к задержкам в диагностике. Взаимодействие лекарственных средств и воспалительный синдром восстановления иммунитета (ВСВИ) осложняют совместное лечение туберкулеза и ВИЧ-инфекции. Короткие режимы профилактической терапии на основе рифапентина эффективны, но доступ к этим режимам ограничен. В этом обзоре рассматриваются последние достижения в области исследований и международных рекомендаций с акцентом на клинические проблемы у взрослых, живущих в странах с высоким бременем заболеваний ВИЧ и туберкулезом.

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